Many of you here use the Amitriptyline and Ketamine cream. I got some and have been trying it for a week. I don’t see a difference. I would have thought I would by now. I know this has helped some, for some did nothing, and irritated others. It looks like I might be in the ‘did nothing’ category, but I wondered if for those it worked how long it took to notice a difference.
I read a CRPS study saying anti pain effects of topical ketamine were noticed after 1-2 wks.
A case study for amit/ket topical and an EM patient, says she got relief 2 days later.
But no idea on the average. Topical ketamine made me worse so I had to stop using that one immediately
edit to include source of the CRPS “1-2 wks” :
T Ushida, T Tani, T Kanbara, VS Zinchuk, M Kawasaki and H Yamamoto,
Regional anesthesia and pain medicine, Sep-Oct 2002
Ketamine hydrochloride (KET), an agent used for general anesthesia, has local anesthetic effects and N-methyl-D-aspartate (NMDA) receptor antagonist action. Because recent studies emphasized the role of peripherally distributed NMDA receptors in processing the nociceptive information, we investigated whether peripheral application of the ointment containing KET is able to attenuate the symptoms of local neuropathic pain.We applied ointment containing KET (0.25%-1.5%) to the affected area on limbs in 5 patients with complex regional pain syndrome type I (CRPS I) and in 2 patients with type II (CRPS II). One to 2 weeks later, we observed improvement of the report of pain intensity, measured by the visual analog scale, in 4 patients with acute early dystrophic stage of CRPS I. Swelling of the affected limbs subsided as well. No apparent changes were noticed in 1 patient with chronic atrophic stage of CRPS I and in both patients with CRPS II.Topical application of KET appears to be beneficial for the patients with acute early dystrophic stage of CRPS I because of either its local anesthetic effect or NMDA receptor antagonist action. Patients with chronic atrophic stage of CRPS I and CRPS II patients do not appear to respond to this treatment.
and EM retrospective study saying avg # times of application / day was 5 (doesn’t say how long of a trial to give it…)