Ketamine- reinventing chronic pain management

Have you tried either topical, oral or infusions of ketamine for the management of EM pain?

Low-dose ketamine infusion; also called the "Awake Technique" based on hypothesis that ketamine manipulates NMDA receptors which might reboot aberrant brain activity.A 2004 article discussing ketamine infusion therapy states, "Although ketamine may have more than one mechanism of action, the basis for using it to treat CRPS may reside in its strong ability to block NMDA receptors. Experimental evidence suggests that a sufficiently intense or prolonged painful stimulus causes an extraordinary release of glutamate from peripheral nociceptive afferents onto dorsal horn neurons within the spinal cord. The glutamate released, in turn, stimulates NMDA receptors on second-order neurons that produce the phenomena of windup and central sensitization. It is reasonable to consider that, by blocking NMDA receptors, one might also be able to block cellular mechanisms supporting windup and central sensitization [4–7,15]. Ketamine is the only potent NMDA-blocking drug currently available for clinical use. Our interpretation is that an appropriately prolonged infusion of ketamine appears to maintain a level of ketamine in the central nervous system long enough to reverse the effects of the sensitization process and associated pain." see

We have touched on this topic very briefly before:

Low dose ketamine infusion helps young girl - Japanese case study

I haven't tried any of theses but would be interested in finding out if others have and if it helped. This is one of the few treatment options left I haven't tried.

I have not tried Ketamine, but it sounds like it might have some good results if administered correctly under the right conditions.

Thank you for taking the time to share your experience with us Veerla. I am sure this will be helpful information for both members considering this treatment as well as for those that have already made the decision to go ahead with it but are nervous about what to expect during their upcoming hospital stay.
I have certainly been there as far as having constant severe pain 24/7 and I just wanted to be admitted to a hospital and had a comma induced till it was over but no surprise here no one would do that for me. This was from before we knew what was wrong with me. I am fortunate though I respond to lifestyle change and as long as I keep my house between 55 and 63 and I don’t move around that much I can minimize my flares so it’s no longer 24/7 for me.
I still get them but I am blessed with some time most days where I have a break from the pain. Even if just for a couple of hours those small breaks make a huge difference on my moral.
I hope you are able to get even a little time in your days where you can get some rest and relief from your pain.

I tried a compounded cream of 2% amitriptyline and 1% Ketamine three times daily for seven days; it was not effective.

Hi Guys,

We seem to have two posts on ketamine going. Here is link to other :-)