Methadone for pain management

I came across this on You Tube , Doctor has prescribed this young girl methadone for pain management and on this evidence it appears to be successful. Controversial, maybe? Has anyone been tried on methadone for EM?

http://www.youtube.com/watch?v=n1cAagt_h6A

I know of several people, particularly youngsters, who are being treated for CRPS/EM with Methadone with some success, though usually in combination with other medications.

I think this is a form of cocain to give addicts to help them get off of the more dangerous drug,.....what say?

I think a little research goes a long way. Methadone is an opioid, coming from the poppy flower. Cocaine comes from the leaves of the coca plant. Methadone is used for people with opioid dependence, be it prescription or otherwise. Methadone can be abused, but it's not as common as hydrocodone, or oxcycontin.

Betty Rhodes said:

I think this is a form of cocain to give addicts to help them get off of the more dangerous drug,.....what say?

Methadone is the only opioid that has any effectiveness with nerve pain. My son was on methadone, trilpetal, mexiletine, amitriptyline, and alprazolam when he was released from the hospital.

Hi, im on high dose of methadone for CRPS and have been for 5 years- find it to be best treatment prog yet although saying that its not perfect- I take with along with oxycontin for breakthrough pain. Some folk maintain tramadol , amitryptiline helps. Personally codeine helped me in early days before i became so chronic...... depends on cause/nature of pain. Anti inflammatories like naproxen can help certain types too.

Nerve pain - Drs tend to push gabapentin/pregabalin for neuropathic pain. Helps some/others not. Thats the nature of chronic pain- finding the drug , dosage and medication package for you.

Methadone ,or any opioid or other treatment doesnt touch my EM. As a rule most research concludes opioids do not help.... and can exacerbate EM treatment to my knowledge goes two ways - SSR serotonin route (you can test yourself on this - SAME test, see Dr Cohens work) or sodium channel blockers(lidocaine infusion test). Seems to depend on what type EM, Many other things can attempt to make symptoms more manageable. Either way no known cure (as yet!) Im on mexil trial for EM and things seem to be happening slowly after 3 months. Im really hopeful.

God bless

mads

Hi, Thanks for he information is your Son currently pain and drug free? or does he have to take medicine to keep things at bay?



Asher'sMom said:

Methadone is the only opioid that has any effectiveness with nerve pain. My son was on methadone, trilpetal, mexiletine, amitriptyline, and alprazolam when he was released from the hospital.

He's pain and med free.

That's fantastic, its what we are hoping for.

Hi,

Apologies for the late reply to this thread but I've been in hospital for ages.

I started taking methadone after seeing the same video. I have primary early-onset erythromelalgia, which is what I believe your daughter has. I'm undergoing genetic testing for the SCN9A variant at them moment too and keeping everything crossed that XEN402 and XEN403 get licensed soon.

Methadone has not helped my pain. The one thing I would say is that if it is not working, get your daughter off it as soon as you can. This is because of one of the lesser known effects of methadone. It can cause withdrawl symptoms lasting months, or even permenent withdrawl symptoms. Although I am still taking the drug, withdrawl symptoms are possibly what is causing me a lot of pain at the moment.

If you are still trying to get her onto the drug, the withdrawl effect needs to be taken into account so that she can be taken off it quickly if it doesn't work. It would be better to put her onto another opiate and reduce that, rather than keep her on methadone.

You may also hear that methadone works for 24 hours. That is only an average. It can work for anywhere between 7 and 60 hours, depending on the individual.

I hope your daughter is having better results.

Dear Starsmurf,

So happy to see you back!

The paucity of research that actually exists concludes that opioids do not help EM. I know some people may beg to differ, and thats great. Im thrilled if anything out there helps anyone of us . Methadone , however, doesnt touch my EM. Like you i have tried probably every drug going. I am in agreement that it can exacerbate matters.Being a seasoned high dose methadone taker for CRPS , I find methadone only helps with bone related pain .

God bless

mads

Hi Starsmurf,

The mere mention of methadone gets the doctors backs raised. My Daughter goes in on Monday for three days of High dose intravenous methylprednisolone pulse therapy. It has shown some efficacy in the treatment of EM and many other conditions. We are hoping once again that this is the magic bullet however we have been here before and all we can do is hope.

Methadone was something I had read about in the search for some relief for Her, flares are fairly constant and She s miserable as you might expect.



mads said:

Dear Starsmurf,

So happy to see you back!

The paucity of research that actually exists concludes that opioids do not help EM. I know some people may beg to differ, and thats great. Im thrilled if anything out there helps anyone of us . Methadone , however, doesnt touch my EM. Like you i have tried probably every drug going. I am in agreement that it can exacerbate matters.Being a seasoned high dose methadone taker for CRPS , I find methadone only helps with bone related pain .

God bless

mads

David, It will be interesting to know what happens when you drop aspirin. After my operation I was on tramadol, Gabapentin, MST, paracetamol and liquid morphine top ups but still I begged for my aspirin because it gave me the only reLief I’ve ever had for EM. Not surprisingly I can remember very little of those post op dAys.

Hi All,

I am on morphine plus other drugs. I have considered
going to methadone after see this video from UCSF.
http://www.uctv.tv/shows/Advances-in-Non-Operative-Pain-Management-A-Spectrum-of-Options-23154 Pain management specialist Dr. Melanie Henry prefers methadone to morphine. I am quoting here, compared to
morphine methadone is inexpensive, may provide improved analgesia in
neuropathic pain and will provide a long duration of action. Methadone, a
potent opioid agonist has many characteristics that make it useful for the
treatment of pain My pain management Dr. tells me it uses one more receiptor than the
opioids.

She (pain management specialist professor, Dr. Melanie
Henry) says it's her go to drug for neuropathic pain. She is not alone in this
opinion. I believe there has been a recent study to support her views.

Here are some other intersting videos.

http://www.uctv.tv/shows/The-Science-of-Pain-23157

http://www.uctv.tv/pain101/

http://www.uctv.tv/shows/Pain-and-the-Brain-13074

http://www.uctv.tv/shows/Pain-Management-Update-12838

My best.

Fixme and everyone else!.

Hi Dkel
Just realised I never replied to the query ‘what are you on now?’. Sorry. I take aspirin, a small amount but I am convinced it helps, Clonazepam at night to cut down the myoclonic jerks that come with the heat and a double dose of cetirizine. I took myself off Gabapentin and while I was prescribed Losartan I haven’t taken it because I am on heart medications and it just seemed like a dose too far. Since I am discouraged from taking paracetamol because it interferes with Warfarin I have been thinking to ask for tramadol which they gave me in hospital.
Nel

dkel9307 said:
Thanks Nel

I have a suspicion I will still need it! Thanks, because it is good to see someone else in similar situation.

What are you on now?

Kind regards

David

Hi Guys,

I am on methadone- I have been for many years . Medically ,despite being used in neuropathic and bone related pain, no evidence that it helps EM- opiates( to my knowledge/my experience), generally dont.Infact reported that opiate type drugs can exacerbate flares. I really need to clarify some misunderstanding too. You cant just take methadone- it doesnt work like morphine ie: immediate effect.Methadone needs to be tritated up and its levels sustained as it has half life. As a rule you are hospitalised for couple of days or longer - monitored due to its toxicity. Methadone initially makes you feel pretty ill- sickness, dizziness, drugged out of it.... quite horrible. Anyone who can tolerate methadone, as part of their pain management, will generally require an accompanying' breakthrough' pain relief such as oxycontinin, tramadol . Methadone is under strict FDA regulation .

Several medications out there known to help with better management of symptoms to varying degrees such as calcuim or soduim channel blockers, aspirin, gabapentin/pregabalin, antihistamines, iloprost .etc..

God bless

mads