My derm suggested I try ranexa. Tried searching the forum for it but found nothing. Was wondering if anyone tried it, had good/bad rxns to it. Took one pill, had off the charts burning … so I’m nervous to try again …
Ranexa is used for angina really but is a sodium channel blocker like mexiletine.
Since I just had no response to a couple months of mexiletine, it seems like my derm might be checked out / eager to prescribe anything to get me out of his office (?)
gabapentin (better for a while then made me worse)
lyrica (helps with pain, but sedating)
doxepin (no change)
amlodipine (better for a while then worse)
midodrine (massively worse)
effexor, cymbalta, paxil, remeron, no anti-depressant (no change)
topical ketamine 10% / amit 2% (rebound)
plaquenil (no change)
antihistamines (better for a while then nothing)
propranolol (improvement, but depression SE)
NSAID’s (no change)
… not sure what else atm.
On a related note, my dad and brother have similar symptoms as me (evening burning). If I failed mexiletine, would it be worth it at all to check for the sodium channel mutation?
Thanks for any thoughts. Would really like to be able to work again!